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KMID : 0381219700020020033
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Journal of RIMSK
1970 Volume.2 No. 2 p.33 ~ p.40
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EFFECTS OF CORTICOSTEROID ON ARTHRITIC DISEASE
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Abstract
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The effects of Corticosteroids on rheumatic arthritis;
The effects of adrenal hormone and adrenocorticoticotropic hormone have come to be widely known since the Kendall and his associates reported in 1949. Corticosteroid hormone had been used extensively for the treatment of various inflammatory conditions including rheumatoid arthritis and senile degenerative arthritis until a serious and unpleasant side effect of the steroid was reported by many authors.
Even though the adrenal cortical hormone has not curative effect in rheumatoid arthritis and degenerative arthritis, pain. stiffness, swelling and tenderness are usually relieved in a few days, with marked improvement in mental out-look. Sedimentation rate decreases, low hemoglobin rises, and serum proteins tend to return toward the normal pattern. But fortunately, on discontinuing the drug, symptoms and laboratory findings revert toward the original state or become even worse.
Hollander has reported that local infiltration of steroid into the arthritic lesion is superior with less toxic side-effects to systematic administration, even though Charcot´s change, avascular necrosis and secondary infection may be caused by the continuous local infiltration.
Steroid has been proved to be an effective temporary ante-inflammatory agent for the rheumatoid arthritis, degenerative osteoarthritis and gouty arthritis, but histologically it has not curative effects. Local infiltration of steroid into the arthritic lesion should be limited to not more than five or six times with Hydrocortisone acetate 25 mg or methyl prednisolone acetate 40 mg at an interval of one or two weeks because it dose not have a curative effect on the arthritic lesions but temporary soothing and analgesic effects.
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